期刊
TETRAHEDRON
卷 63, 期 38, 页码 9365-9372出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2007.06.113
关键词
spirooxindole; aqueous medium; three-component synthesis
A simple and efficient one-pot three-component synthesis of the biologically important spirooxindoles scaffold was carried out by the reaction of isatin, activated methylene reagent, and 1,3-dicarbonyl compounds in aqueous medium. This method is of great value because of its environmentally benign character, high yield processing, and easy handling. (C) 2007 Elsevier Ltd. All rights reserved.
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