Copper(II) triflate as a double catalyst for the one-pot click synthesis of 1,4-disubstituted 1,2,3-triazoles from benzylic acetates

Copper(II) triflate doubly catalyzed the substitution of benzylic acetates by TMSN3 and the subsequent 1,3-dipolar addition with an alkyne in one pot. This procedure afforded the preparation of 1,4-disubstituted 1,2,3-triazoles in good yields starting from the easily accessible acetates without isolating an organic azide using a single catalyst.