期刊
TETRAHEDRON LETTERS
卷 48, 期 39, 页码 7038-7041出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2007.07.129
关键词
Fmoc amino acids; tetrazoles; unnatural amino acids; [2+3] cycloaddition
An efficient synthesis of tetrazole analogues of amino acids starting from N-alpha-Fmoc amino acid in a three-step protocol is reported. The free amino tetrazoles were obtained in good yields and with excellent purity after removal of the Fmoc group. The synthesis of analogues of aspartic and glutamic acids in which the 5-tetrazolyl moiety is inserted at the beta/gamma carboxyl group starting from Fmoc-Asn and Fmoc-Gln and the incorporation of these tetrazoles into peptides are also described. (c) 2007 Elsevier Ltd. All rights reserved.
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