Tetrabutylammonium fluoride-induced dehydrobromination of vinyl bromides to terminal acetylenes

Tetrabutylammonium fluoride (TBAF) was found to be a mild and efficient base for the dehydrobromination of vinyl bromides. Treatment of various 2-bromo-1-alkenes with TBAF-3H(2)O in DNIF yielded terminal acetylenes in high yields without undue regard to the presence of water. (C) 2007 Elsevier Ltd. All rights reserved.