期刊
CHEMICAL PHYSICS LETTERS
卷 446, 期 1-3, 页码 151-158出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.cplett.2007.07.095
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资金
- NIGMS NIH HHS [S06 GM008102-350088, S06 GM008102] Funding Source: Medline
The electronic properties of double-stranded octametric DNA-DNA and LNA-DNA with a single-base mismatch were compared with those having fully complementary base pairs to quantify the effect of the base mismatch on hybridization energies (HE). A single T-G mismatch in the LNA-DNA gives rise to a significant reduction in HE, which is consistent with a significant lowering of the melting temperature for mismatched LNA-DNA. By contrast, the hybridization strength of the mismatched DNA DNA depends strongly on local hydrogen-bonding arrangements in the mispaired T-G. The difference in HE is explained in terms of variation in charge distributions around the hydrogen-bonded base pairs. (C) 2007 Elsevier B.V. All rights reserved.
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