期刊
BRAIN RESEARCH BULLETIN
卷 74, 期 4, 页码 271-277出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.brainresbull.2007.06.021
关键词
central nervous system; blood-brain barrier; neurotrophic factor; olfactory pathway; trigeminal pathway; neuroprotection
This study is aimed to evaluate the brain distribution of transforming growth factor-beta 1 (TGF-beta 1) following intranasal administration and the subsequent biological effects of TGF-beta 1. Adult rats were given recombinant human TGF-beta 1 (rhTGF-beta 1) or vehicle solution intranasally. TGF-beta 1 concentrations were significantly raised in several brain regions and the trigeminal nerve following intranasal delivery. The elevation appeared within 30 min and was sustained for at least 6 h, reaching its greatest level at 60 min. A concentration gradient in the central nervous system (CNS) regions was produced during the first 2 h after intranasal administration, with the OB presenting a significantly higher concentration than any other CNS regions. The nasally administered TGF-beta 1 subsequently regulated gene expressions of its two receptors (TGF-beta receptor types I and II) in vivo, but did not affect mRNA level of TGF-beta 1 itself. Our results suggest that TGF-beta 1 can be transported into the CNS via the olfactory and trigeminal pathways, and may consequently exert its biological effects by regulating gene expressions of its receptors. Intranasal administration of neurotrophic factors may offer a potential strategy for treating some CNS disorders. (c) 2007 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据