期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 72, 期 20, 页码 7567-7573出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo070829x
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[GRAPHICS] The reaction of chiral (2R,1'S)- or (2S,1'S)-2-(1-aminoalkyl)epoxides 1 or 2 with CO2, generated from acidic treatment of an aqueous solution of NaHCO3 at room temperature, efficiently afforded enantiopure cyclic carbonates 3 or 4, respectively, with total selectivity. Compounds 3 and 4 were readily transformed into the corresponding diols 7 and 8 by reaction with LiAlH4 or by basic hydrolysis. When compounds 3 or 4 were allowed to react with methyllithium at -78 degrees C, O-1-acetylalkane-1,2-diols 9 and 10 were obtained with total or high selectivity.
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