期刊
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
卷 158, 期 2-3, 页码 224-236出版社
ELSEVIER
DOI: 10.1016/j.resp.2007.03.005
关键词
high-altitude hypoxia; permanent; intermittent; adaptation; age; reversibility; heart; protection; molecular mechanisms; hypertrophy
This review deals with the capability of the heart to adapt to chronic hypoxia in animals exposed to either natural or simulated high altitude. From the broad spectrum of related issues, we focused on the development and reversibility of both beneficial and adverse adaptive myocardial changes. Particular attention was paid to cardioprotective effects of adaptation to chronic high-altitude hypoxia and their molecular mechanisms. Moreover, interspecies and age differences in the cardiac sensitivity to hypoxia-induced effects in various experimental models were emphasized. (c) 2007 Elsevier B.V. All rights reserved.
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