期刊
MOLECULES
卷 12, 期 10, 页码 2348-2363出版社
MDPI
DOI: 10.3390/12102348
关键词
antitumor; cytotoxicity; mass spectrometry; multinuclear NMR; organotin
A series of mono-, di- and triorganotin compounds with general formulae [RSnL2Cl], R = Bu ( compound 3), [R2SnL2], where R = Me, Et, Bu, Oct ( compounds 1, 2, 4 and 6) and [R3SnL], where R = Bu, Cy and Ph ( compounds 5, 7 and 8) and where L = 3,4-methylenedioxy-6-nitrophenylpropenoic acid have been prepared and characterized by elemental analysis, multinuclear (H-1-, C-13- and Sn-119-) NMR and mass spectrometry. The ligand and its respective organotin complexes were screened for cytotoxicity using the brine shrimp lethality assay and for antitumor activity using the crown gall tumor inhibition ( potato disc) assay. The bioassay results support the conclusion that the biological activities of these synthetic compounds are in the following order: [ RSnL2Cl] < [ R2SnL2] < [ R3SnL].
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据