期刊
CELL CYCLE
卷 6, 期 19, 页码 2332-2338出版社
LANDES BIOSCIENCE
DOI: 10.4161/cc.6.19.4914
关键词
breast cancer; tumor heterogeneity; cancer stem cells; clonal evolution
类别
资金
- NCI NIH HHS [CA94074, CA89393] Funding Source: Medline
Breast tumors are composed of a variety of cell types with distinct morphologies and behaviors. It is not clear how this tumor heterogeneity comes about. Two popular concepts that attempt to explain this are the cancer stem cell hypothesis and the clonal evolution model. Each of these ideas has been investigated for some time, leading to the accumulation of numerous findings that are used to support one or the other. Although the two views share some similarities, they are fundamentally different notions with very different clinical implications. Analysis of the research backing each concept, along with a review of the results of our recent study investigating putative breast cancer stem cells, suggests how the cancer stem cell hypothesis and the clonal evolution model may be involved in generating breast tumor heterogeneity. An understanding of this process will allow the development of more effective ways to treat and prevent breast cancer.
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