期刊
NEUROTHERAPEUTICS
卷 4, 期 4, 页码 571-579出版社
SPRINGER
DOI: 10.1016/j.nurt.2007.07.002
关键词
neuroinflammation; TREM; microglia; Alzheimer's disease; multiple sclerosis; purinergic receptors; P2Y12
资金
- NIMH NIH HHS [MH067121] Funding Source: Medline
- NINDS NIH HHS [R01 NS045735-02, R01 NS039508-03, R01 NS039508, R01 NS039508-04, R01 NS045735-04, R01 NS045735-05, R01 NS045735-01, R01 NS039508-06, R01 NS039508-05, R01 NS045735-03, R01 NS039508-02, NS045735, R01 NS039508-01A1S1, NS039508, R01 NS045735, R01 NS039508-01A1] Funding Source: Medline
Microglial activation and macrophage infiltration into the CNS are common features of CNS autoimmune disease and of chronic neurodegenerative diseases. Because these cells largely express an overlapping set of common macrophage markers, it has been difficult to separate their respective contributions to disease onset and progression. This problem is further confounded by the many types of macrophages that have been termed microglia. Several approaches, ranging from molecular profiling of isolated cells to the generation of irradiation chimeric rodent models, are now beginning to generate rudimentary definitions distinguishing the various types of microgha and macrophages found within the CNS and the potential roles that these cells may play in health and disease. Key Words- neuroinflammation, TREM, microglia, Alzheimer's disease, multiple sclerosis, purinergic receptors, P2Y12.
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