期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 18, 期 5, 页码 698-706出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2007.08.012
关键词
interphase chromosome; chromatin mobility; nuclear organization
资金
- NIGMS NIH HHS [R01 GM042516-15, R01 GM058460-06, R01 GM058460-05, R01 GM058460, GM42516, R01 GM042516-14, R01 GM058460-07, R01 GM042516, R01 GM058460-08, R01 GM042516-16, R01 GM042516-17, GM58460] Funding Source: Medline
The past decade has seen an increasing appreciation for nuclear compartmentalization as an underlying determinant of interphase chromosome nuclear organization. To date, attention has focused primarily on describing differential localization of particular genes or chromosome regions as a function of differentiation, cell cycle position, and/or transcriptional activity. The question of how exactly interphase chromosome compartmentalization is established and in particular how interphase chromosomes might move during changes in nuclear compartmentalization has received less attention. Here we review what is known concerning chromatin mobility in relationship to physiologically regulated changes in nuclear interphase chromosome organization. (C) 2007 Elsevier Ltd. All rights reserved.
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