One-pot synthesis of 1,3-thiazolidin-4-ones derivatives from 2-amino-1,3,4-thiadiazole

Several 1,3-thiazolidin-4-ones were synthesized by cyclocondensation reaction of 2-amino-1,3,4-thiadiazole, mercaptoacetic acid and various arenealdehydes in moderate to good yields. These compounds were characterized by I H, C-13 and F-19 NMR. The antimalarial activity of thiazolidinones was evaluated in vitro against Plasmodium falciparum clone but none of them showed activity at maximum concentration (50 mu g/ml) used.