期刊
JOURNAL OF MAGNETIC RESONANCE IMAGING
卷 26, 期 4, 页码 1122-1126出版社
JOHN WILEY & SONS INC
DOI: 10.1002/jmri.21118
关键词
fMRI; multisite studies; reproducibility of results; variance components analysis; motor task
资金
- Medical Research Council [G90/96] Funding Source: Medline
- MRC [G90/96] Funding Source: UKRI
- Medical Research Council [G90/96] Funding Source: researchfish
Purpose: To estimate between-scanner functional MRI (fMRI) reproducibility in a multisite study. Materials and Methods: A total of five identical 1.5T MR systems were used to repeatedly scan five subjects while performing a finger tapping task. A two-way (scanners, subjects) random effects analysis of variance (ANOVA) was used to estimate between-scanner and between-subject variability on two outcome variables: task-related mean blood oxygenation level dependent (BOLD) signal change and volume of activation within a motor region-of-interest (ROI). Results: Between-scanner variability of fMRI data accounted for a small proportion of the total variation in the BOLD signal change (8.34%, P = 0.114) and volume of activation (5.46%, P = 0.203). Between-subject variation accounted for more than half of the total variation for both measurements (57.17% and 54.46%, respectively, P < 0.01). Conclusion: These results support the feasibility of multisite studies using identical scanner systems.
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