期刊
ARCHIVES OF NEUROLOGY
卷 64, 期 10, 页码 1482-1487出版社
AMER MEDICAL ASSOC
DOI: 10.1001/archneur.64.10.1482
关键词
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Objective: To determine if functional connectivity of the hippocampus is reduced in patients with Alzheimer disease. Design: Functional connectivity magnetic resonance imaging was used to investigate coherence in the magnetic resonance signal between the hippocampus and all other regions of the brain. Participants: Eight patients with probable Alzheimer disease and 8 healthy volunteers. Results: Control subjects showed hippocampal functional connectivity with diffuse cortical, subcortical, and cerebellar sites, while patients demonstrated markedly reduced functional connectivity, including an absence of connectivity with the frontal lobes. Conclusion: These findings suggest a functional disconnection between the hippocampus and other brain regions in patients with Alzheimer disease.
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