期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 51, 期 10, 页码 3771-3774出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00099-07
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Vancomycin dispositions in the respiratory system were compared after systemic and inhalatory administration under two respiratory conditions using the isolated-lung model. Inhalatory delivery led to much higher drug levels in pulmonary tissue and fluids. The respiratory pattern affects vancomycin disposition in the pulmonary system regardless of the administration route.
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