期刊
BEHAVIORAL NEUROSCIENCE
卷 121, 期 5, 页码 877-886出版社
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/0735-7044.121.5.877
关键词
food reinforcement; energy intake; obesity; dopamine; dopamine receptor
资金
- NICHD NIH HHS [R01 HD 39778, R01 HD057975, R01 HD039778-06, R01 HD039778] Funding Source: Medline
The authors measured food reinforcement, polymorphisms of the dopamine D-2 receptor (DRD2) and dopamine transporter (DATI) genes, and laboratory energy intake in 29 obese and 45 nonobese humans 18-40 years old. Food reinforcement was greater in obese than in nonobese individuals, especially in obese individuals with the TaqI A] allele. Energy intake was greater for individuals high in food reinforcement and greatest in those high in food reinforcement with the TaqI A I allele. No effect of the DATI genotype was observed. These data show that individual differences in food reinforcement may be important for obesity and that the DRD2 genotype may interact with food reinforcement to influence energy intake.
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