期刊
CELL CALCIUM
卷 42, 期 4-5, 页码 351-361出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ceca.2007.02.011
关键词
in vivo calcium imaging; molecular biosensors; indicator proteins; neuronal networks
类别
Fluorescence imaging represents a powerful approach for the detection of intracellular Ca2+ signals in vivo. With appropriate techniques, Ca2+ signals can be recorded at many levels of complexity, ranging from large scale neuronal networks down to individual presynaptic boutons or postsynaptic spines. Here we review the applicability of genetically encoded Ca2+ indicators for in vivo Ca2+ imaging of neural function. We describe some of the recent progress in sensor design and evaluate the performance of the new family of Troponin C-based Ca2+ indicators. Further, we analyze properties of Ca2+ biosensors transgenically expressed in various experimental animal models and illustrate their use for measuring somatic and dendritic Ca2+ signals in neurons of the mammalian brain. (c) 2007 Elsevier Ltd. All rights reserved.
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