期刊
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
卷 305, 期 2, 页码 243-251出版社
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.ijmm.2014.12.007
关键词
Adenylate cyclase; HAMP domain; Signaling language; Membrane receptor
资金
- Deutsche Forschungsgemeinschaft [SFB 766, TP B8]
HAMP domains are small protein modules that predominantly operate as signal transducers in bacterial sensor proteins most of which are membrane delimited. The domain organization of such sensors has the HAMPs localized at the intersection between the membrane-anchored input sensor and the cytosolic output machinery. The data summarized here indicate that HAMP modules use a universal signaling language in balancing the communication between diverse membrane-bound input domains and cytosolic output domains that are completely foreign to each other. (C) 2014 Elsevier GmbH. All rights reserved.
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