期刊
EPIDEMIOLOGY AND INFECTION
卷 135, 期 7, 页码 1133-1144出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0950268806007783
关键词
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资金
- Engineering and Physical Sciences Research Council [GR/S43214/01] Funding Source: researchfish
To determine the potential benefits of regionally targeted mass vaccination as an adjunct to other smallpox control strategies we employed a spatial metapopulation patch model based on the administrative districts of Great Britain. We counted deaths due to smallpox and to vaccination to identify strategies that minimized total deaths. Results confirm that case isolation, and the tracing, vaccination and observation of case contacts can be optimal for control but only for optimistic assumptions concerning, for example, the basic reproduction number for smallpox (R-o = 3) and smaller numbers of index cases (similar to 10). For a wider range of scenarios, including larger numbers of index cases and higher reproduction numbers, the addition of mass vaccination targeted only to infected districts provided an appreciable benefit (5-80% fewer deaths depending on where the outbreak started with a trigger value of 1-10 isolated symptomatic individuals within a district).
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