期刊
EXPERT REVIEW OF VACCINES
卷 6, 期 5, 页码 685-698出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/14760584.6.5.685
关键词
adsorption mechanism; aluminum hydroxide adjuvant; aluminum phosphate adjuvant; antigen trapping; antigen uptake; dendritic cell maturation; isoelectric point; recruitment of antigen-presenting cells; t-cell activation; t-cell differentiation
类别
Aluminum-containing adjuvants are an important component of many vaccines because they safely potentiate the immune response. The structure and properties of aluminum hydroxide adjuvant, aluminum phosphate adjuvant and alum-precipitated adjuvants are presented in this review. The major antigen adsorption mechanisms, electrostatic attraction and ligand exchange, are related to the adjuvant structure. The manner by which aluminum-containing adjuvants potentiate the immune response is related to the structure, properties of the adjuvant and adsorption mechanism. Immunopotentiation occurs through the following sequential steps: inflammation and recruitment of antigen-presenting cells, retention of antigen at the injection site, uptake of antigen, dendritic cell maturation, T-cell activation and T-cell differentiation.
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