期刊
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
卷 389, 期 4, 页码 1003-1016出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-007-1449-y
关键词
peptide modifications; covalent modifications; tandem mass spectrometry; neutral loss; marker ions
Collision-induced reporter fragmentations of the currently most important covalent peptide modifications as detected by tandem mass spectrometry are summarized. These fragmentations comprise the formation of reporter ions, which are preferentially immonium ions, immonium ion-derived fragments or side chain fragments. In addition, the reporter neutral loss reactions for covalently modified amino acid residues are summarized. For each individual covalent modification which can be recognized by a reporter fragmentation, the accurate mass shift and the gross formula shift of the modified amino acid residue are given. The same set of data is provided for the reporter fragmentations. Finally, an extensive accurate mass and gross formula list is presented as supplementary material, describing mostly regular and modified y(1) and dipeptide a and b ions, which are helpful for identification of the peptide ends of covalently modified peptides.
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