期刊
MAGNETIC RESONANCE IN MEDICINE
卷 58, 期 4, 页码 786-793出版社
JOHN WILEY & SONS INC
DOI: 10.1002/mrm.21387
关键词
magnetization transfer; MT; z-spectrum; asymmetry; CEST; amide proton transfer; human brain
资金
- NCRR NIH HHS [RR015241, P41 RR015241-10, P41 RR015241] Funding Source: Medline
- NIBIB NIH HHS [EB002634, R01 EB004130, R21 EB002666-01, R01 EB004130-08, R01 EB002634, R21 EB002666-02, R21 EB002666, EB002666, P41 EB015909] Funding Source: Medline
Magnetization transfer (MT) imaging provides a unique method of tissue characterization by capitalizing on the interaction between solid-like tissue components and bulk water. We used a continuous-wave (CW) MT pulse sequence with low irradiation power to study healthy human brains in vivo at 3 T and quantified the asymmetry of the MT effects with respect to the water proton frequency. This asymmetry was found to be a difference of approximately a few percent from the water signal intensity, depending on both the RF irradiation power and the frequency offset. The experimental results could be quantitatively described by a modified two-pool MT model extended with a shift contribution for the semisolid pool with respect to water. For white matter, this shift was fitted to be 2.34 +/- 0.17 ppm (N = 5) upfield from the water signal.
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