期刊
CLINICAL RHEUMATOLOGY
卷 26, 期 10, 页码 1675-1678出版社
SPRINGER
DOI: 10.1007/s10067-007-0568-3
关键词
estrogen; estrogen receptor; RQ-PCR; systemic lupus erythematosus
类别
To investigate the influence of sex hormones on the development of systemic lupus erythematosus (SLE), we examined the estrogen receptor (ER) expression by peripheral blood mononuclear cells (PBMC) in patients with SLE using the real-time quantitative polymerase chain reaction (TaqMan) method. The expression of messenger RNA (mRNA) for ER alpha (ERa) was increased and expression of ER beta (ERb) mRNA was decreased in PBMC from SLE patients compared with PBMC from normal controls. These findings may be useful for elucidation of the pathophysiology of SLE.
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