期刊
MOLECULAR AND CELLULAR BIOLOGY
卷 27, 期 20, 页码 7236-7247出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/MCB.00780-07
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资金
- NCI NIH HHS [R01 CA116097, R01 CA116097-03] Funding Source: Medline
- NEI NIH HHS [EY12825, R01 EY012825] Funding Source: Medline
The size of an organ must be tightly controlled so that it fits within an organism. The mammalian lens is a relatively simple organ composed of terminally differentiated, amitotic lens fiber cells capped on the anterior surface by a layer of immature, mitotic epithelial cells. The proliferation of lens epithelial cells fuels the growth of the lens, thus controlling the size of the lens. We report that the Notch signaling pathway defines the boundary between proliferation and differentiation in the developing lens. The loss of Notch signaling results in the loss of epithelial cells to differentiation and a much smaller lens. We found that the Notch effector Herp2 is expressed in lens epithelium and directly suppresses p57(Kip2) expression, providing a molecular link between Notch signaling and the cell cycle control machinery during lens development.
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