期刊
JOURNAL OF FLUORINE CHEMISTRY
卷 128, 期 10, 页码 1318-1325出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jfluchem.2007.08.001
关键词
benzotrifluorides; (Trifluoromethyl)arenes; methyl trifluoroacetate; alkaline fluorides; alkaline chlorides; trifluoromethylation; aromatic substitution
When associated with an alkaline halide, such as cesium fluoride or cesium chloride, and Cu(I) species, methyl trifluoroacetate (MTFA) constitutes a valuable trifluoromethylatingagent for substituting aromatic (or heteroaromatic) iodides and bromides. The reaction can be carried out in DMF at 180 degrees C or, better, in sulfolane which allows he reaction to proceed at a lower temperature (from 140 degrees C). (C) 2007 Elsevier B.V. All rights reserved.
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