期刊
NATURE GENETICS
卷 39, 期 10, 页码 1273-1277出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng2120
关键词
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资金
- NIGMS NIH HHS [GM 055840, R37 GM043987] Funding Source: Medline
Improper meiotic chromosome segregation causes conditions such as Down's syndrome(1). Recombination promotes proper chromosome segregation in meiosis I; chromosomes without crossovers near the centromere are more likely to segregate to the same spindle pole (nondisjoin). Here we have used budding yeast to determine whether the spindle checkpoint promotes segregation of such chromosomes. In checkpoint-defective mad2 Delta cells, properly segregating chromosomes have more crossovers near the centromere than their wild-type counterparts, and an artificial tether that holds chromosomes together suppresses nondisjunction as long as the tether is near the centromere. The tether partially rescues the segregation of chromosomes that lack crossovers.
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