期刊
EPILEPSY RESEARCH
卷 77, 期 1, 页码 17-21出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.eplepsyres.2007.07.010
关键词
JME; EEG; photosensitivity
Objective: To evaluate if a standard awake EEG recording in the morning is superior to afternoon awake EEG session in detecting generalized epileptiform discharges (GEDs) in patients with juvenile myoclonic epilepsy (JME). Methods: The study group included 29 consecutive patients (23 women; mean age 22.3 +/- 6.3 years; age at onset of JME 15.4 +/- 3.4 years) with JME. Out of 29 patients 5 were untreated, 9 patients were treated with valproate, 8 with lamotrigine, 6 with levetiracetam and 1 patient with valproate plus phenobarbital. Two routine consecutive interictal EEG recordings were performed at 9 a.m. and at 3 p.m., respectively, while the subject was awake, on the same day after a a regular nocturnal sleep at own home. Results: The morning EEG recording showed GEDs (i.e., generalized polispike and waves, photoparoxysmal response, or both). in 20/29 patients. In 15 of these 20 patients, the afternoon recording was normal and this difference was statistically significant (p <= 0.001). Moreover, there was a striking reduction of GEDs in three of the remaining five patients. Nine/29 patients had both morning and afternoon EEG recording normal. Conclusions: The results of this study have illustrated a significant greater rate of detection of generalized epileptiform abnormalities by performing standard awake EEG in the morning in comparison with an afternoon session. (c) 2007 Elsevier B.V. All rights reserved.
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