期刊
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
卷 87, 期 4, 页码 420-425出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbb.2007.05.018
关键词
addiction; cue; MDMA; reinstatement; relapse; self-administration
资金
- NIDA NIH HHS [R01 DA002451-23, F31 DA020209-02, R01 DA002451, DA 02451, R01 DA012964-08, DA 020209, R01 DA012964, F31 DA020209] Funding Source: Medline
The widely used recreational drug MDMA (ecstasy) supports self-administration in animals, but it is not known whether MDMA-associated cues are able to reinstate drug seeking in a relapse model of drug addiction. To assess this possibility, drug-naive rats were trained to press a lever for MDMA infusions (0.30 mg/kg/infusion, i.v.) paired with a compound cue (light and tone) in daily 2 h sessions. Responding was reinforced contingent on a modified fixed-ratio 5 schedule of reinforcement. Conditioned cue-induced reinstatement tests were conducted after lever pressing was extinguished in the absence of MDMA and the conditioned cues. Conditioned cues reinstated lever pressing after extinction, and the magnitude of reinstatement was positively correlated with the level of responding during MDMA self-administration. These results show for the first time that conditioned cues can trigger reinstatement of MDMA-seeking behavior in rats, and that individual differences in the pattern of MDMA self-administration can predict the magnitude of reinstatement responding. (c) 2007 Elsevier Inc. All rights reserved.
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