期刊
NEUROIMAGE
卷 37, 期 4, 页码 1457-1464出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2007.06.028
关键词
fibers; gender; IQ; lateralization; MRI; sex
资金
- NCRR NIH HHS [P41 RR013642, P41 RR013642-04, U54 RR021813, U54 RR021813-05] Funding Source: Medline
- NIA NIH HHS [P50 AG016570-090004, AG016570, P50 AG016570] Funding Source: Medline
- NICHD NIH HHS [HD050735, R01 HD050735] Funding Source: Medline
- NIMH NIH HHS [R01 MH060374-05, MH60374, R01 MH060374, K01 MH073990-04, K01 MH073990] Funding Source: Medline
- NINDS NIH HHS [NS049194] Funding Source: Medline
Callosal morphology is thought to reflect the capacity for interhemispheric communication and thus, in addition to other cerebral characteristics, may serve as a neuroanatomical substrate of general intellectual capacity. We applied novel computational mesh-based methods to establish the presence and direction of correlations between intelligence and callosal thickness at high spatial resolution while removing the variance associated with overall brain size. Within healthy subjects (n = 62), and within males (n = 28) and females (n = 34) separately, we observed significant positive correlations between callosal morphology and intelligence measures (full-scale, performance, and verbal). These relationships were pronounced in posterior callosal sections and were confirmed by permutation testing. Significant negative correlations were absent. Positive associations between intelligence and posterior callosal thickness may reflect a more efficient inter- hemispheric information transfer, positively affecting information processing and integration, and thus intellectual performance. At the same time, regional variations in callosal size might also partly reflect the underlying architecture of topographically connected cortical regions relevant for processing higher-order cognitive information. Our findings emphasize the importance of incorporating posterior (callosal) regions into the theories and models proposed to explain the anatomical substrates of intelligence. (C) 2007 Elsevier Inc. All rights reserved.
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