期刊
NATURE REVIEWS NEUROSCIENCE
卷 8, 期 10, 页码 755-765出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn2212
关键词
-
资金
- Medical Research Council [G9900989] Funding Source: Medline
- MRC [G9900989] Funding Source: UKRI
- Medical Research Council [G9900989] Funding Source: researchfish
Retinoic acid ( RA) is involved in the induction of neural differentiation, motor axon outgrowth and neural patterning. Like other developmental molecules, RA continues to play a role after development has been completed. Elevated RA signalling in the adult triggers axon outgrowth and, consequently, nerve regeneration. RA is also involved in the maintenance of the differentiated state of adult neurons, and disruption of RA signalling in the adult leads to the degeneration of motor neurons ( motor neuron disease), the development of Alzheimer's disease and, possibly, the development of Parkinson's disease. The data described here strongly suggest that RA could be used as a therapeutic molecule for the induction of axon regeneration and the treatment of neurodegeneration.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据