期刊
NATURE GENETICS
卷 39, 期 10, 页码 1197-1199出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng2108
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资金
- Medical Research Council [G0000111] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
- Medical Research Council [G0000111] Funding Source: researchfish
- MRC [G0000111] Funding Source: UKRI
F cells measure the presence of fetal hemoglobin, a heritable quantitative trait in adults that accounts for substantial phenotypic diversity of sickle cell disease and beta thalassemia. We applied a genome-wide association mapping strategy to individuals with contrasting extreme trait values and mapped a new F cell quantitative trait locus to BCL11A, which encodes a zinc-finger protein, on chromosome 2p15. The 2p15 BCL11A quantitative trait locus accounts for 15.1% of the trait variance.
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