期刊
NATURE METHODS
卷 4, 期 10, 页码 822-827出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH1092
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资金
- NCI NIH HHS [CA118696, R33 CA118696-02, R33 CA118696, CA087660, R01 CA087660, R01 CA087660-07] Funding Source: Medline
Activity-based protein profiling ( ABPP), the use of active site-directed chemical probes to monitor enzyme function in complex biological systems, is emerging as a powerful post-genomic technology. ABPP probes have been developed for several enzyme classes and have been used to inventory enzyme activities en masse for a range of ( patho) physiological processes. By presenting specific examples, we show here that ABPP provides researchers with a distinctive set of chemical tools to embark on the assignment of functions to many of the uncharacterized enzymes that populate eukaryotic and prokaryotic proteomes.
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