期刊
JOURNAL OF BIOSCIENCE AND BIOENGINEERING
卷 104, 期 4, 页码 343-346出版社
SOC BIOSCIENCE BIOENGINEERING JAPAN
DOI: 10.1263/jbb.104.343
关键词
liposome-encapsulated hemoglobin (LEH); oxygen carrier; rat hepatocyte; 2D flat-plate bioreactor; liver tissue engineering
We tested the short-term efficacy of liposome-encapsulated hemoglobin (LEH) in cultured rat hepatocytes. Supplementation with LEH (20% of the hemoglobin concentration of blood) did not lower albumin production in static culture, and completely reversed the cell death and deterioration in albumin production caused by an oxygen shortage in 2D flat-plate perfusion bioreactors.
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