期刊
JOURNAL OF APPLIED PHYSIOLOGY
卷 103, 期 4, 页码 1221-1226出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/japplphysiol.00153.2007
关键词
ventilation; hypoxia ventilatory response; moderate altitude
This study tested the hypothesis that the extent of the decrement in Vo(2max) and the respiratory response seen during maximal exercise in moderate hypobaric hypoxia (H; simulated 2,500 in) is affected by the hypoxia ventilatory and hypercapnia ventilatory responses (HVR and HCVR, respectively). Twenty men (5 untrained subjects, 7 long distance runners, 8 middle distance runners) performed incremental exhaustive running tests in H and normobaric normoxia (N) condition. During the running test, Vo(2), pulmonary ventilation (VF) and arterial oxyhemoglobin saturation (Sa(o2)) were measured, and in two ventilatory response tests performed during N, a rebreathing method was used to evaluate HVR and HCVR. Mean HVR and HCVR were 0.36 +/- 0.04 and 2.11 +/- 10.2 l.min(-/-)mmHg(-1), respectively. HVR correlated significantly with the percent decrements in Vo(2max) (%dVo(2max)), Sa(o2) [%dSa(o2) = (N-H).N-1.100], and V-E/V-o2 seen during H condition. By contrast, HCVR did not correlate with any of the variables tested. The increment in maximal V-E between H and N significantly correlated with %dVo(2),Our findings suggest that O-2 chemosensitivity plays a significant role in determining the level of exercise hyperventilation during moderate hypoxia; thus, a higher O-2 chemosensitivity was associated with a smaller drop in Vo(2max) and Sa(o2) under those conditions.
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