期刊
JOURNAL OF PEDIATRIC PSYCHOLOGY
卷 32, 期 9, 页码 1040-1049出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/jpepsy/jsl056
关键词
brain tumor; cognitive deficits; late effects; medulloblastoma
资金
- NCI NIH HHS [P30 CA21765] Funding Source: Medline
Objective Risk-adapted treatment approaches employed within contemporary medulloblastoma treatment protocols aim to reduce the neurotoxicity directed at the central nervous system. Despite these important steps to reduce radiation dose exposure, an overwhelming majority of medulloblastoma survivors continue to experience academic failure and significant learning delays. Methods A review of the current literature is presented. Results Deficits in intellectual function, academic achievement, memory, attention, and processing speed are reported. Finally, intervention programs, including pharmacotherapy and experimental cognitive intervention studies, are discussed. A review of neuroimaging studies shows changes in brain tissue following chemotherapy and radiation treatment. Conclusions Declining IQ and academic struggles may be predated by difficulties with attention, memory, and processing speed. More clinical trials directed at treating and preventing neurocognitive late effects through cognitive rehabilitation are needed.
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