期刊
JOURNAL OF CHILD NEUROLOGY
卷 22, 期 10, 页码 1198-1203出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0883073807306265
关键词
epilepsy; autism; pervasive developmental disorder not otherwise specified
Data on epilepsy in pervasive developmental disorder not otherwise specified are few and scanty Seventy-seven patients with pervasive developmental disorder not otherwise specified were compared with 77 with autistic disorder, matched for age and sex. The 2 groups were divided into 3 subgroups each: A, without electroencephalography (EEG) paroxysmal abnormalities or epilepsy, 13, with EEG paroxysmal abnormalities without epilepsy; and C, with epilepsy. Mild mental retardation (P <.0 1), pathological neurological examination (P <.05), cerebral lesions (P <.01), abnormal EEG background activity (P <.001), and associated genetic pathologies (P <.01) were more common in pervasive developmental disorder not otherwise specified. Familial antecedents for epilepsy prevailed in subgroup C (P<.01). Epilepsy occurred in 35.1% of patients with pervasive developmental disorder not otherwise specified, with no statistically significant difference compared with autistic disorder. The mean age of seizure onset was earlier (2 years 8 months) in pervasive developmental disorder not otherwise specified (P <.000). Seizure outcome was better in autistic disorder. Genetic diseases and cerebral lesions should be investigated in pervasive developmental disorder not otherwise specified to clarify the etiological and clinical features.
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