期刊
HEARING RESEARCH
卷 232, 期 1-2, 页码 29-43出版社
ELSEVIER
DOI: 10.1016/j.heares.2007.06.007
关键词
stem cell; hearing loss; spiral ganglion; hair cell
资金
- NIDCD NIH HHS [F32 DC005866, R01 DC001689-16A1, F32 DC005866-03, F32 DC05866-02, R01 DC001689-14, R01 DC001689-15] Funding Source: Medline
Most cases of hearing loss are caused by the death or dysfunction of one of the many cochlear cell types. We examined whether cells from a neural stem cell line could replace cochlear cell types lost after exposure to intense noise. For this purpose, we transplanted a clonal stem cell line into the scala tympani of sound damaged mice and guinea pigs. Utilizing morphological, protein expression and genetic criteria, stem cells were found with characteristics of both neural tissues (satellite, spiral ganglion, and Schwann cells) and cells of the organ of Corti (hair cells, supporting cells). Additionally, noise-exposed, stem cell-injected animals exhibited a small but significant increase in the number of satellite cells and Type I spiral ganglion neurons compared to non-injected noise-exposed animals. These results indicate that cells of this neural stem cell line migrate from the scala tympani to Rosenthal's canal and the organ of Corti. Moreover, they suggest that cells of this neural stem cell line may derive some information needed from the microenvironment of the cochlea to differentiate into replacement cells in the cochlea. (C) 2007 Elsevier B.V. All rights reserved.
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