期刊
CLINICAL NEUROPHYSIOLOGY
卷 118, 期 10, 页码 2128-2148出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.clinph.2007.04.019
关键词
P300; P3a; P3b; ERP; attention memory; neuropsychology; neurotransmitters; inhibition; theory
资金
- NIAAA NIH HHS [3 P50 AA06420, P50 AA006420, P60 AA006420-230018] Funding Source: Medline
- NIDA NIH HHS [R01 DA018262, R01-DA018262, R01 DA018262-04, R01 DA018262-05] Funding Source: Medline
The empirical and theoretical development of the P300 event-related brain potential (ERP) is reviewed by considering factors that contribute to its amplitude, latency, and general characteristics. The neuropsychological origins of the P3a and P3b subcomponents are detailed, and how target/standard discrimination difficulty modulates scalp topography is discussed. The neural loci of P3a and P3b generation are outlined, and a cognitive model is proffered: P3a originates from stimulus-driven frontal attention mechanisms during task processing, whereas P3b originates from temporal-parietal activity associated with attention and appears related to subsequent memory processing. Neurotransmitter actions associating P3a to frontal/dopaminergic and P3b to parietal/norepinephrine pathways are highlighted. Neuroinhibition is suggested as an overarching theoretical mechanism for P300, which is elicited when stimulus detection engages memory operations. (C) 2007 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
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