期刊
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
卷 101, 期 3, 页码 369-375出版社
SPRINGER
DOI: 10.1007/s00421-007-0513-9
关键词
transcranial Doppler; near-infrared spectroscopy; posture; head-down tilt
Continuous positive airway pressure (CPAP) is a treatment modality for pulmonary oxygenation difficulties. CPAP impairs venous return to the heart and, in turn, affects cerebral blood flow (CBF) and augments cerebral blood volume (CBV). We considered that during CPAP, elevation of the upper body would prevent a rise in CBV, while orthostasis would challenge CBF. To determine the body position least affecting indices of CBF and CBV, the middle cerebral artery mean blood velocity (MCA V-mean) and the near- infrared spectroscopy determined frontal cerebral hemoglobin content (cHbT) were evaluated in 11 healthy subjects during CPAP at different body positions (15 degrees head-down tilt, supine, 15 degrees, 30 degrees and 45 degrees upper body elevation). In the supine position, 10 cm H2O of CPAP reduced MCA V (mean) by 9 +/- 3% and increased cHbT by 4 +/- 2 mu mol/L (mean +/- SEM); (P < 0.05). In the head-down position, CPAP increased cHbT to 13 +/- 2 mu mol/L but left MCA V (mean) unchanged. Upper body elevation by 15 degrees attenuated the CPAP associated reduction in MCA V (mean) (-7 +/- 2%), while cHbT returned to baseline (1 +/- 2 mu mol/L). With larger elevation of the upper body MCA V (mean) decreased progressively to -17 +/- 3%, while cHbT remained unchanged from baseline. These results suggest that upper body elevation by 15 degrees during 10 cm H2O CPAP prevents an increase in cerebral blood volume with minimal effect on cerebral blood flow.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据