期刊
BIOLOGY OF THE CELL
卷 99, 期 10, 页码 583-600出版社
WILEY
DOI: 10.1042/BC20070034
关键词
actin; ADP-ribosylation factor (Art); ASAP1; focal adhesion; GTPase-activating protein; invadopodia
类别
资金
- Intramural NIH HHS Funding Source: Medline
The Arf (ADP-ribosylation factor) GAPs (GTPase-activating proteins) are a family of proteins with a common catalytic domain that induces hydrolysis of GTP bound to Arf GTP-binding proteins. At least three groups of multiclomain Arf GAPs affect the actin cytoskeleton and cellular activities, such as migration and movement, that depend on the cytoskeleton. One role of the Arf GAPs is to regulate membrane remodelling that accompanies actin polymerization. Regulation of membrane remodelling is mediated in part by the regulation of Arf proteins. However, Arf GAPs also regulate actin independently of effects on membranes or Arf. These functions include acting as upstream regulators of Rho family proteins and providing a scaffold for Rho effectors and exchange factors. With multiple functional elements, the Arf GAPs could integrate signals and biochemical activities that result in co-ordinated changes in actin and membranes necessary for a wide range of cellular functions.
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