期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 15, 期 19, 页码 6489-6496出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2007.04.010
关键词
benzimidazoles; thiazolidinone; schiff bases; EBV-EA; induction
As a continuation to our previous work concerning antitumor benzimidazoles, we have synthesized series of new derivatives of 2-(1-benzyl-2-methyl-1H-benzimidazol-5-ylimino)-3-(substituted)-thiazolidin-4-one (6a-e), 3-(2-methy]-1H-benzimidazol-5-yl)-2-substituted-thiazolidin-4-one (9a-f) and we have studied their inhibitory activity against the Epstein-Barr Virus-early antigen (EBV-EA) activation introduced by 12-O-tetradecanoylphorbol- 13-acetate (TPA). Compound 6d was found to be significantly active and compounds 5a and 6e were also active. (C) 2007 Elsevier Ltd. All rights reserved.
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