期刊
NEUROBIOLOGY OF AGING
卷 28, 期 10, 页码 1484-1492出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2007.05.005
关键词
normal cognition; stereology; nucleus; hypertrophy
资金
- Intramural NIH HHS [Z01 AG000191-11] Funding Source: Medline
- NIA NIH HHS [P50 AG005146, AG16282, R01 AG016282, P50 AG005146-249003, P50 AG005146-240030, AG 05146, R01 AG016282-07] Funding Source: Medline
- NINDS NIH HHS [NS52098, R01 NS052098-01A1, R01 NS052098] Funding Source: Medline
This study focuses on the morphometric changes of neurons in asymptomatic Alzheimer's disease (AD), a state characterized by the presence of AD lesions in subjects without cognitive impairment. In autopsy brains, we used stereological methods to compare the cell body and nuclear volumes of anterior cingulate gyrus (ACG) and CAI hippocampal neurons in asymptomatic AD subjects (11 = 9), subjects with AD dementia (AD, n = 8), mild cognitive impairment (MCI, it = 9), and age-matched controls (controls, n = 9). In ACG, we observed a significant decrease in the neuronal volume of MCI and AD compared to controls; by contrast, no atrophy was present in asymptomatic AD. Moreover, we found a significant increase in nuclear volume in asymptomatic AD compared to controls (P < 0.00 1), MCI (P < 0.0 1) and AD (P < 0.00 1) brains. Similar results were found in the CA I region of the hippocampus. This nuclear hypertrophy may represent an early neuronal reaction to AP or Tau, or a compensatory mechanism which forestalls the progression of AD and a] lows the brain to resist the development of dementia. (c) 2007 Elsevier Inc. All rights reserved.
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