期刊
CELL CYCLE
卷 6, 期 19, 页码 2417-2421出版社
LANDES BIOSCIENCE
DOI: 10.4161/cc.6.19.4779
关键词
H5N1; influenza; Mx1; polymerase; protection
类别
资金
- PHS HHS [HHSN266200700005C] Funding Source: Medline
We investigated the importance of the host Mx1 gene in protection against highly pathogenic H5N1 avian influenza virus. Mice expressing the Mx1 gene survived infection with the lethal human H5N1 isolate A/Vietnam/ 1203/04 and with reassortants combining its genes with those of the non-lethal virus A/chicken/Vietnam/C58/04, while all Mx1(-/-) mice succumbed. Mx1-expressing mice showed lower organ virus titers, fewer lesions, and less pulmonary inflammation. Our data support the hypothesis that Mx1 expression protects mice against the high pathogenicity of H5N1 virus through inhibition of viral polymerase activity ultimately resulting in reduced viral growth and spread. Drugs that mimic this mechanism may be protective in humans.
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