期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 17, 期 19, 页码 5423-5427出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2007.07.033
关键词
cinnamaldehyde; apoptosis; cell cycle
A series of cinnamyl compounds related to 2'-hydroxycinnamaldehyde were synthesized and their antitumor effects against human cancer cells evaluated. Hydroxylamine derivative 6 inhibited the growth of human cancer cells and human colon tumor xenograft in nude mice. Its antitumor effects belong to the induction of apoptosis and arresting cell cycle at G(2)/M phase, which is confirmed by detection of apoptosis markers and cell cycle analysis. (C) 2007 Elsevier Ltd. All rights reserved.
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