期刊
NANO LETTERS
卷 7, 期 10, 页码 3071-3079出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl071547f
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资金
- NIBIB NIH HHS [R01 EB006261, EB02332, R01 EB002332, R01 EB009663] Funding Source: Medline
- NIDCR NIH HHS [R01 DE015391, RC2 DE020767, RC2 DE020767-02, DE15391] Funding Source: Medline
Long-term labeling of stem cells during self-replication and differentiation benefits investigations of development and tissue regeneration. We report the labeling of human mesenchymal stem cells (hMSCs) with RGD-conjugated quantum dots (QDs) during self-replication, and multilineage differentiations into osteogenic, chondrogenic, and adipogenic cells. QD-labeled hMSCs remained viable as unlabeled hMSCs from the same subpopulation. These findings suggest the use of bioconjugated QDs as an effective probe for long-term labeling of stem cells.
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