期刊
CYTOKINE & GROWTH FACTOR REVIEWS
卷 18, 期 5-6, 页码 381-388出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2007.06.012
关键词
2-5A; RNase L; interferon; cancer; virus
资金
- NCI NIH HHS [R01 CA044059, CA044059, R01 CA044059-23] Funding Source: Medline
The antiviral and antitumor actions of interferons are caused, in part, by a remarkable regulated RNA cleavage pathway known as the 2-5A/RNase L system. 2 '-5 ' linked oligoadenylates (2-5A) are produced from ATP by interferon-inducible synthetases. 2-5A activates pre-existing RNase L, resulting in the cleavage of RNAs within single-stranded regions. Activation of RNase L by 2-5A leads to an antiviral response, although precisely how this happens is a subject of ongoing investigations. Recently, RNase L was identified as the hereditary prostate cancer 1 gene. That finding has led to the discovery of a novel human retrovirus, XMRV. My scientific journey through the 2-5A system recounts some of the highlights of these efforts. Knowledge gained from studies on the 2-5A system could have an impact on development of therapies for important viral pathogens and cancer. (c) 2007 Elsevier Ltd. All rights reserved.
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