期刊
GENES & DEVELOPMENT
卷 21, 期 19, 页码 2422-2432出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1588407
关键词
lymphatic endothelial cells; lymphangiogenesis; Prox1; mouse; lineage tracing; Runx1
资金
- NCI NIH HHS [P30 CA021765, CA-21765] Funding Source: Medline
- NHLBI NIH HHS [HL 076448, R01-HL073402, R01 HL076448, R01 HL073402] Funding Source: Medline
The origin of the mammalian lymphatic vasculature has been debated for more than 100 years. Whether lymphatic endothelial cells have a single or dual, venous or mesenchymal origin remains controversial. To resolve this debate, we performed Cre/loxP-based lineage-tracing studies using mouse strains expressing Cre recombinase under the control of the Tie2, Runx1, or Prox1 promoter elements. These studies, together with the analysis of Runx1-mutant embryos lacking definitive hematopoiesis, conclusively determined that from venous-derived lymph sacs, lymphatic endothelial cells sprouted, proliferated, and migrated to give rise to the entire lymphatic vasculature, and that hematopoietic cells did not contribute to the developing lymph sacs. We conclude that the mammalian lymphatic system has a solely venous origin.
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