期刊
CURRENT OPINION IN GENETICS & DEVELOPMENT
卷 17, 期 5, 页码 435-442出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2007.08.004
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资金
- Intramural NIH HHS [Z01 BC010309-08] Funding Source: Medline
Chromatin is increasingly recognized as a highly dynamic entity. Chromosome sites in lower and higher eukaryotes undergo frequent, rapid, and constrained local motion and occasional slow, long-range movements. Recent observations have revealed some of the functional relevance of chromatin mobility. Paradoxically, both the mobility and immobility of chromatin appear to have functional consequences: Local diffusional motion of chromatin is important in gene regulation, but global chromatin immobility plays a key role in maintenance of genomic stability.
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