期刊
SEMINARS IN CANCER BIOLOGY
卷 17, 期 5, 页码 403-410出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2007.05.001
关键词
black raspberries; colon; esophagus; cancer; prevention
类别
资金
- NCI NIH HHS [R01 CA96130, R01 CA096130-03, R01 CA 103180, R01 CA103180-05, R01 CA103180-02, R01 CA103180-03, R01 CA103180-04, R01 CA103180, R01 CA096130-03S1, R01 CA103180-01, R01 CA096130] Funding Source: Medline
Our laboratory is developing a food-based approach to the prevention of esophageal and colon cancer utilizing freeze-dried berries and berry extracts. Dietary freeze-dried berries were shown to inhibit chemically induced cancer of the rodent esophagus by 30-60% and of the colon by up to 80%. The berries are effective at both the initiation and promotion/progression stages of tumor development. Berries inhibit tumor initiation events by influencing carcinogen metabolism, resulting in reduced levels of carcinogen-induced DNA damage. They inhibit promotion/progression events by reducing the growth rate of pre-malignant cells, promoting apoptosis, reducing parameters of tissue inflammation and inhibiting angiogenesis. On a molecular level, berries modulate the expression of genes involved with proliferation, apoptosis, inflammation and angiogenesis. We have recently initiated clinical trials; results from a toxicity study indicated that freeze-dried black raspberries are well tolerated in humans when administered orally for 7 days at a dose of 45 g per day. Several Phase IIa clinical trials are underway in patients at high risk for esophagus and colon cancer; i.e., Barrett's esophagus, esophageal dysplasia and colonic polyps, to determine if berries will modulate various histological and molecular biomarkers of development of these diseases. (c) 2007 Elsevier Ltd. All rights reserved.
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